ABSTRACT
Astroblastoma is an uncommon glial tumor with predominant manifestation in the young age. Herein, we report a case of 18-year-old astroblastoma female patient who presented with history of two months headache. Magnetic resonance imaging (MRI) of the brain demonstrated well circumscribed, intra-axial abnormal signal intensity lesion (size=5×4 cm²) in the right parieto-occipital region of the brain. The patient underwent complete surgical resection of the gross tumor, as confirmed by an early post-surgical MRI (i.e., within 24 hours of surgery). Histopathological examination revealed neoplastic lesion exhibiting perivascular pseudo-rosettes with centrally hyalinized blood vessel and focal nuclear pleomorphism. Immunohistochemistry staining illustrated reactivity for glial fibrillary acidic protein and integrase interactor 1 (INI-1). These features rendered the diagnosis of astroblastoma. A comprehensive review of the current literature to summarize the clinicopathological and radiological characteristics, prognostic factors and current treatment strategies of astroblastomas is also presented. Our study would expand the pool of this uncommon tumor towards its better understanding and optimal treatment.
Subject(s)
Adolescent , Female , Humans , Blood Vessels , Brain , Brain Neoplasms , Craniotomy , Diagnosis , Glial Fibrillary Acidic Protein , Headache , Hyalin , Immunohistochemistry , Integrases , Magnetic Resonance Imaging , Neoplasms, NeuroepithelialABSTRACT
Purpose/Background: the majority of cancers affect older persons because aging is a high risk factor for this disease. Gastrointestinal tract malignancies are also considered disease that affects older patients, with a peak incidence in the sixth and seventh decades. Close to 60% of all newly diagnosed malignant tumors and 71% of all cancer deaths occur in persons in this age group according to the NCI surveillance, epidemiology and end results [SEER] program data. Aging population is more vulnerable to develop cancer caused by a lifetime exposure to carcinogen such as pollution, radiation, tobacco and harmful sunrays etc
Objective: the objective of this research was to study the gastrointestinal tract [GIT] malignancies in different age groups in our set up
Design: retrospective study
Duration: from January 2001 to December 2010
Method: this 10 year review of patients with GIT cancers in different age groups was carried out at the Centre for Nuclear medicine and Radiotherapy [CENAR], Quetta south western region of Pakistan. Information extracted from the files of patients in record
Results: out of 2269 patients, the most common age group was above 60 year with a total of 752[33%] patients. Among1178 patients of carcinoma [Ca] esophagus, 30% belong to above 60year age group, Whereas above 60 year age group is commonest age group for CaColorectum, Stomach, Liver, Gall bladder, Pancreas, Small intestine and Anal canal accounting for 35%, 37%, 40%, 37%, 36%, 40% and 33% respectively
Conclusion: malignancy is associated with old age. Various GIT malignancies studied in our study showed that above 60 year age group being commonest
ABSTRACT
To assess the most common type of GIT tumor, most common site of this tumor, Sex and staging in people of Balochistan including patients from Afghanistan. Retrospective, Analytic study. This study was carried out at the was carried out at the Centre for Nuclear Medicine and Radiotherapy [CENAR], Quetta from January 2001 to December 2010. 8324 cases of different malignancies were seen over the 10 year period with an average of 833 cases/ year. This 10 year review of patients with GIT cancers was carried out at the Centre for Nuclear Medicine and Radiotherapy [CENAR], Quetta. Information extracted from the cases notes of patients in record i.e. most common type of tumor, most common site of this tumor, sex and staging. The most common type was GIT tumors with a total of 2278 patients. GIT cancer occur among male most commonly, the esophagus being the most commonest site and mostly [more than half] presented cases are in Stage III and Stage IV. This result shows that in Balochistan including adjustant Afghanistan most common type of cancer/malignancy was GI among all malignancies. GI malignancy occurs among male most commonly, the esophagus being the most common site. Mostly [more than half] presented cases are in Stage III and Stage IV cases. Cancer management is a global health problem specially in this part due to lack of awareness, early diagnosis, better treatment system in multidisciplinary team as indicated in this article need of future research in G.I.T and other tumors
ABSTRACT
Background / Purpose: The study was conducted to evaluate the Breast cancer patients with metastasis to different body regions
Aims and Objectives: The primary aim was to highlight the most common site of metastasis and different Sonographic patterns in breast cancer patients at CENAR, Quetta. The secondary aim was to determine the average age of breast carcinoma [Ca] presentation
Material and Methods: A two year retrospective study of breast carcinoma diagnosed and treated at our centre was conducted. 278 patients pathologically proven invasive carcinoma breast were registered at CENAR from 1st January 2010 to December 2011 were analyzed
Results: During the study period, 278 patients were registered as Ca breast patients out of which 109 [39%] patients developed metastasis during or after treatment or initially at registration, majority of the patients were with liver metastasis 46 [42%]patients and most common Sonographic pattern was hypo echoic with 26[57%] patients. Most common age group was 25-40 years with 125[45%] patients, followed by 41-55 years with 97[35%] patients
ABSTRACT
Aims and Objectives: A retrospective study of all thyroid patients registered at the centre of Nuclear Medicine and Radiotherapy [CENAR], Quetta from 1st January2010 to December 2011[02years]. The aim of this study was to highlight gender and age wise distribution of hypothyroid and hyperthyroid patients in CENAR Quetta
Study design: A retrospective study
Place and Duration: A retrospective study of 2051 files of Thyroid patients was carried out in CENAR Quetta from1st January 2010 to December 2011 [02years]
Results: Out of 2051 patients, the most common gender was female with a total of 1442 [Hypothyroid female: 487; Hyperthyroid female: 231; Euthyroid female: 724] and the common age group was 16-40yr with a total of 1453[16-40yr Hypothyroid male: 153 and Female: 337; 16-40yr Hyperthyroid male: 113 and Female: 139; 16-40yr Euthyroid male: 158 and Female: 553]
ABSTRACT
Plasmacytoma is a rare B- lymphocyte neoplastic disorder that usually presents as the generalized disease multiple myeloma. Less than 5% of cases present as a solitary mass of monoclonal plasma cells in the bone or soft tissue. Although solitary osseous Plasmacytoma may arise in any bone, while Sternal involvement is uncommon. We report here a case of solitary plasmacytoma of sternum in a 55 years old male patient without signs and symptoms suggestive of multiple myeloma. Patient was treated with radiation therapy with a dosage of 40 Gy in 20 fractions
ABSTRACT
Aims and Objectives: A retrospective study of allcancer registered cases at the Center for NuclearMedicine and Radiotherapy [CENAR] Quetta From1st Jan, 1998 to 31st December 2009[12 Years] wascarried out. CENAR Quetta is the only cancermanagement center in Balochistan. The aim of thisanalysis was to highlight the prevalence of Cancerin Balochistan
Study Design: A retrospectivestudy
Place and duration of Study: The study wasconducted at CENAR Quetta
Results: During thestudy period, 12022 cancer patients were registeredat CENAR and BMCH Quetta. Out of these 10924files of patients [91.19%] were analyzed. The datawere analyzed from various angles of prevalencee.g. total number of registered cancer patients, Sex,Age, Histopathology, Demographic profile etc
Conclusion: As cancer management is a globalchallenging health problem including Pakistan, sothe first step for all health program worldwide is tohighlight the prevalence, incidence and etiologicalfactors of the disease in the locality, for step wisegoing towards management and control
ABSTRACT
Primary ovarian lymphoma presenting with ovarianmass as a primary disease is extremely rare. Wereport here a case of primary ovarian B-cell non-Hodgkin's lymphoma with bilateral involvementwhich was managed by surgery and chemotherapy.A 35 years old woman was admitted with signs andsymptoms suggestive of ovarian cancer. Thediagnosis of malignant lymphoma was establishedafter bilateral adnexectomy, histological andimmunohistochemical study of the excised tissue.The stage was I ES according to Ann-Arbor stagingsystem. The patient was planned for R-CHOPchemotherapy, but due to unaffordbility patient wastreated with 06 cycles of standard CHOP regimenand had completed her treatment. She has now beenon follow-up and is without disease from 15 monthsof treatment